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For the neurotoxic profile, reducing GABA synthesis inhibition or preventing the transformation into the toxic state through microglia modulation have demonstrated improvements in cognitive outcomes 58,134

Causal relationships among GLP-1RA exposure, peripheral taste-pathway modulation, central reward-circuit activity, altered liking, reduced wanting, and long-term dietary behaviour remain incompletely established, and alternative explanations such as nausea-related aversion, delayed gastric emptying, altered satiety, expectancy effects, dietary compensation, medication adherence, and psychological or behavioural moderators should also be considered

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